With the increase of the level of complexity， integration and intelligence of missile weapon system， health management technology， as a key enabling technology to improve equipment reliability， testability， maintainability and supportability， has gotten more and more attention and application. Based on the health management needs of the new generation missile weapon system， the design principle， structural framework， workflow and life cycle data management requirements of missile equipment health management system are introduced. The feasibility and effectiveness of the design method in the development of health management system are verified by taking certain equipment as an example.